PoinnCARE: Hyperbolic Multi-Modal Learning for Enzyme Classification

Enzyme Commission (EC) number prediction is vital for elucidating enzyme functions and advancing biotechnology applications. However, current methods struggle to capture the hierarchical relationships among enzymes and often overlook critical structural and active site features. To bridge this gap, we introduce PoinnCARE 1 , a novel framework that jointly encodes and aligns multi-modal data from enzyme sequences, structures, and active sites in hyperbolic space. By integrating graph diffusion and alignment techniques, PoinnCARE mitigates data sparsity and enriches functional representations, while hyperbolic embedding preserves the intrinsic hierarchy of the EC system with theoretical guarantees in low-dimensional spaces. Extensive experiments on four datasets from the CARE benchmark demonstrate that PoinnCARE consistently and significantly outperforms state-of-the-art methods in EC number prediction.