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ACL Findings2024

Multi-modal Concept Alignment Pre-training for Generative Medical Visual Question Answering

Quan Yan, Junwen Duan, Jianxin Wang

Abstract

Medical Visual Question Answering (Med-VQA) seeks to accurately respond to queries regarding medical images, a task particularly challenging for open-ended questions. This study unveils the Multi-modal Concept Alignment Pre-training (MMCAP) approach for generative Med-VQA, leveraging a knowledge graph sourced from medical image-caption datasets and the Unified Medical Language System. MMCAP advances the fusion of visual and textual medical knowledge via a graph attention network and a transformer decoder. Additionally, it incorporates a Type Conditional Prompt in the fine-tuning phase, markedly boosting the accuracy and relevance of answers to open-ended questions. Our tests on benchmark datasets illustrate MMCAP's superiority over existing methods, demonstrating its high efficiency in data-limited settings and effective knowledge-image alignment capability.

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Cited by top-tier papers3

  1. X-FLoRA: Cross-modal Federated Learning with Modality-expert LoRA for Medical VQAMin Hyuk Kim, Changheon Kim, Seok Bong YooEMNLP 2025 · 2 citations
  2. CMID: Towards Medical Visual Question Answering via Contrastive Mutual Information DecodingZhihong Zhu, Yunyan Zhang, Fan Zhang, Bowen Xing et al.AAAI 2026 · 1 citation
  3. Dual-Level Confidence based Implicit Self-Refinement for Medical Visual Question AnsweringMeihong Pan, Yefeng ZhengCVPR 2026

Builds on5

  1. Learning Transferable Visual Models From Natural Language SupervisionAlec Radford, Jong Wook Kim, Chris Hallacy, Aditya Ramesh et al.ICML 2021 · 47,906 citations
  2. Visual Instruction TuningHaotian Liu, Chunyuan Li, Qingyang Wu, Yong Jae LeeNeurIPS 2023 · 11,349 citations
  3. BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language ModelsJunnan Li, Dongxu Li, Silvio Savarese, Steven C. H. HoiICML 2023 · 7,873 citations
  4. Medical Visual Question Answering via Conditional ReasoningLi-Ming Zhan, Bo Liu, Lu Fan, Jiaxin Chen et al.ACM MM 2020 · 157 citations
  5. MedICaT: A Dataset of Medical Images, Captions, and Textual ReferencesSanjay Subramanian, Lucy Lu Wang, Ben Bogin, Sachin Mehta et al.EMNLP Findings 2020 · 90 citations

Related papers

  1. MLeVLM: Improve Multi-level Progressive Capabilities based on Multimodal Large Language Model for Medical Visual Question AnsweringDexuan Xu, Yanyuan Chen, Jieyi Wang, Yue Huang et al.ACL Findings 2024 · 14 citations
  2. Alignment, Mining and Fusion: Representation Alignment with Hard Negative Mining and Selective Knowledge Fusion for Medical Visual Question AnsweringYuanhao Zou, Zhaozheng YinCVPR 2025
  3. Enhancing Medical Large Vision-Language Models via Alignment DistillationAofei Chang, Ting Wang, Fenglong MaAAAI 2026
  4. MedKInstruct: A Multimodal Knowledge Graph Based Framework for Multi-Hop and Hard-Negative Instruction Data Synthesis in MedVQAYinan Wu, Jihang Jin, Xuhao Bao, Weiyan Zhang et al.ACL Findings 2026 · 1 citation
  5. PromptCap: Prompt-Guided Image Captioning for VQA with GPT-3Yushi Hu, Hang Hua, Zhengyuan Yang, Weijia Shi et al.ICCV 2023 · 91 citations
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