A Multimodal EEG-Eye Movement Model for Automatic Depression Detection

Depression is a prevalent mental health disorder characterized by persistent sadness and a diminished interest in daily activities, early detection of depression facilitates timely intervention, mitigating its adverse effects. Electroencephalography (EEG) signals and eye movements are emerging as promising biomarkers for depression detection due to their non-invasive nature and cost-effectiveness. Nevertheless, existing studies suffer from methodological constraints, including low specificity, insufficient sample sizes, limited generalizability, and difficulties in large-scale replication, which collectively undermine their clinical utility. To address these challenges, we collected a large-scale depression dataset comprising EEG and eye movements from 1,060 individuals diagnosed with depression and 1,308 healthy controls. To efficiently leverage multimodal data for automatic depression detection, we propose the EEG-Eye Movements Model (E 2 Mo). E 2 Mo employs modality-specific encoders to extract discriminative multi-view features from each modality and incorporates a mixture-of-modality-experts architecture with multi pretraining tasks to achieve efficient and robust modality alignment and fusion. Our approach achieves a 70.06% balanced accuracy by leveraging multi-modal data, demonstrating the effectiveness of integrating EEG signals and eye movements for automatic depression detection.