Towards Generalizable Retina Vessel Segmentation with Deformable Graph Priors

Retinal vessel segmentation is critical for medical diagnosis, yet existing models often struggle to generalize across domains due to appearance variability, limited annotations, and complex vascular morphology. We propose GraphSeg, a variational Bayesian framework that integrates anatomical graph priors with structure-aware image decomposition to enhance cross-domain segmentation. GraphSeg factor-izes retinal images into structure-preserved and structure-degraded components, enabling domain-invariant representation. A deformable graph prior, derived from a statistical retinal atlas, is incorporated via a differentiable alignment and guided by an unsupervised energy function. Experiments on three public benchmarks (CHASE, DRIVE, HRF) show that GraphSeg consistently outperforms existing methods under domain shifts. These results highlight the importance of jointly modeling anatomical topology and image structure for robust generalizable vessel segmentation. Code can be found at github.com/AI4MOL/GraphSeg.