DrHouse: An LLM-empowered Diagnostic Reasoning System through Harnessing Outcomes from Sensor Data and Expert Knowledge

Large language models (LLMs) have the potential to transform digital healthcare, as evidenced by recent advances in LLMbased virtual doctors. However, current approaches rely on patient's subjective descriptions of symptoms, causing increased misdiagnosis. Recognizing the value of daily data from smart devices, we introduce a novel LLM-based multi-turn consultation virtual doctor system, DrHouse, which incorporates three significant contributions: 1) It utilizes sensor data from smart devices in the diagnosis process, enhancing accuracy and reliability. 2) DrHouse leverages continuously updating medical databases such as Up-to-Date and PubMed to ensure our model remains at diagnostic standard's forefront. 3) DrHouse introduces a novel diagnostic algorithm that concurrently evaluates potential diseases and their likelihood, facilitating more nuanced and informed medical assessments. Through multi-turn interactions, DrHouse determines the next steps, such as accessing daily data from smart devices or requesting in-lab tests, and progressively refines its diagnoses. Evaluations on three public datasets and our self-collected datasets show that DrHouse can achieve up to an 18.8% increase in diagnosis accuracy over the state-of-the-art baselines. The results of a 32-participant user study show that 75% medical experts and 91.7% patients are willing to use DrHouse.