Make Model Transparent: Brain Network Analysis via Causal and Knowledge Graph Learning

Brain network analysis technology reveals the organizational mechanism and information processing mode by constructing the structural connection network between brain regions. It has achieved satisfactory results in brain disease prediction tasks, promoting the progress of neuroscience. In recent years, graph transformer has become the most mainstream method for brain analysis with its powerful feature extraction ability and attention mechanism. However, these methods face two challenges, i.e., lack of interpretability, and neglect of semantic associations among brain regions. To solve these problems, we proposed a large language model (LLM)-driven causal knowledge brain network transformer framework, termed BrainCKT, which is plug-and-play, and can adapt to most of the existing mainstream graph transformer-based methods. Specifically, we constructed a brain region causal graph and used its adjacency matrix to guide the learning process of the self-attention mechanism. In addition, we constructed a brain science knowledge graph and encoded it through a pre-trained model to enhance the original brain region features. Finally, we integrated BrainCKT into four mainstream graph transformer baselines for verification. Experimental results on two brain imaging datasets proved the effectiveness of BrainCKT.