SMART: Self-Weighted Multimodal Fusion for Diagnostics of Neurodegenerative Disorders

Multimodal medical data, such as brain scans and non-imaging clinical records like demographics and neuropsychology examinations, play an important role in diagnosing neurodegenerative disorders, e.g., Alzheimer's disease (AD) and Parkinson's disease (PD). However, the disease-relevant information is overwhelmed by the high-dimensional image scans and the massive non-imaging data, making it a challenging task to fuse multimodal medical inputs efficiently. Recent multimodal learning methods adopt deep encoders to extract features and simple concatenation or alignment techniques for feature fusion, which suffer the representation degeneration issue due to the vast irrelevant information. To address this challenge, we propose a deep self-weighted multimodal relevance weighting approach, which leverages clustering-based constrastive learning and eliminates the intra- and inter-modal irrelevancy. The learned relevance score is integrated as a gate with a multimodal attention transformer to provide an improved fusion for the final diagnosis. Our proposed model, called SMART (Self-weighted Multimodal Attention-and-Relevance gated Transformer), is extensively evaluated on three public AD/PD datasets and achieves state-of-the-art (SOTA) performance in the diagnostics of neurodegenerative disorders. Our source code is available at https://github.com/Qybc/SMART.