Multi-dimensional Neural Decoding with Orthogonal Representations for Brain-Computer Interfaces

Current brain-computer interfaces primarily decode single motor variables, limiting their ability to support natural, highbandwidth neural control that requires simultaneous extraction of multiple correlated motor dimensions. We introduce Multi-dimensional Neural Decoding (MND), a task formulation that simultaneously extracts multiple motor variables (direction, position, velocity, acceleration) from single neural population recordings. MND faces two key challenges: crosstask interference when decoding correlated motor dimensions from shared cortical representations, and generalization issues across sessions, subjects, and paradigms. To address these challenges, we propose OrthoSchema, a multi-task framework inspired by cortical orthogonal subspace organization and cognitive schema reuse. OrthoSchema enforces representation orthogonality to eliminate cross-task interference and employs selective feature reuse transfer for fewshot cross-session, subject and paradigm adaptation. Experiments on macaque motor cortex datasets demonstrate that OrthoSchema significantly improves decoding accuracy in cross-session, cross-subject and challenging cross-paradigm generalization tasks, with larger performance improvements when fine-tuning samples are limited. Ablation studies confirm the synergistic effects of all components are crucial, with OrthoSchema effectively modeling cross-task features and capturing session relationships for robust transfer. Our results provide new insights into scalable and robust neural decoding for real-world BCI applications.