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Latent Drifting in Diffusion Models for Counterfactual Medical Image Synthesis

Yousef Yeganeh, Azade Farshad, Ioannis Charisiadis, Marta Hasny, Martin Hartenberger, Björn Ommer, Nassir Navab, Ehsan Adeli

2025Year
4Top-tier citations

Abstract

ing enables diffusion models to be conditioned for medical images fitted for the complex task of counterfactual image generation, which is crucial to investigate how parameters such as gender, age, and adding or removing diseases in a patient would alter the medical images. We evaluate our method on three public longitudinal benchmark datasets of brain MRI and chest X-rays for counterfactual image generation. Our results demonstrate significant performance gains in various scenarios when combined with different fine-tuning schemes.

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