Knowledge-Enhanced Explainable Hypergraph Convolution Network for Medication Recommendation

Medication recommendation systems aim to provide personalized and safe medication options based on individual patient records. However, existing approaches often face challenges related to inadequate modeling of complex relationships within Electronic Health Records (EHRs), data sparsity, and a lack of explainability for recommendations. In this paper, we present a Knowledge-enhanced Explainable Hy-perGraph Convolution Network (KEHGCN) that constructs a hierarchical hypergraph structure to capture the multi-level relationships within EHR data. By incorporating external knowledge graphs, our approach introduces additional positive relations that help alleviate the impact of data sparsity on model learning. Furthermore, by performing generalized metapath construction and selection on the knowledge graph, our approach achieves effective knowledge filtering and extracts semantically meaningful metapaths, thereby further enhancing the explainability of the recommendation results. We also explicitly introduce negative relations present in the domain knowledge to improve the safety of medication recommendation. Extensive experiments on different hospital departments of MIMIC-III and MIMIC-IV datasets demonstrate that KEHGCN outperforms other state-of-the-art baselines.