Brant: Foundation Model for Intracranial Neural Signal
Daoze Zhang, Zhizhang Yuan, Yang Yang, Junru Chen, Jingjing Wang, Yafeng Li
Abstract
We propose a foundation model named Brant for modeling intracranial recordings, which learns powerful representations of intracranial neural signals by pre-training, providing a large-scale, off-the-shelf model for medicine. Brant is the largest model in the field of brain signals and is pre-trained on a large corpus of intracranial data collected by us. The design of Brant is to capture long-term temporal dependency and spatial correlation from neural signals, combining the information in both time and frequency domains. As a foundation model, Brant achieves SOTA performance on various downstream tasks (i.e. neural signal forecasting, frequency-phase forecasting, imputation and seizure detection), showing the generalization ability to a broad range of tasks. The low-resource label analysis and representation visualization further illustrate the effectiveness of our pre-training strategy. In addition, we explore the effect of model size to show that a larger model with a higher capacity can lead to performance improvements on our dataset. The source code and pre-trained weights are available at: https://zju-brainnet.github. io/Brant.github.io/ .
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Cited by top-tier papers5
- Brant-X: A Unified Physiological Signal Alignment FrameworkDaoze Zhang, Zhizhang Yuan, Junru Chen, Kerui Chen et al.KDD 2024 · 13 citations
- EvoBrain: Dynamic Multi-Channel EEG Graph Modeling for Time-Evolving Brain NetworksRikuto Kotoge, Zheng Chen, Tasuku Kimura, Yasuko Matsubara et al.NeurIPS 2025 · 9 citations
- BaRISTA: Brain Scale Informed Spatiotemporal Representation of Human Intracranial Neural ActivityLucine L. Oganesian, Saba Hashemi, Maryam M. ShanechiNeurIPS 2025 · 7 citations
- A foundation model with multi-variate parallel attention to generate neuronal activityFrancesco S. Carzaniga, Michael Hersche, Abu Sebastian, Kaspar Schindler et al.ICLR 2026 · 6 citations
- BraSTORM: A Dual-Branch Self-Supervised Framework for EEG Representation Learning via Input-Level Spatio-Temporal DecompositionYifan Wang, Der-Horng Lee, Bruce X. B. YuAAAI 2026
Builds on7
- Self-Supervised Contrastive Pre-Training For Time Series via Time-Frequency ConsistencyXiang Zhang, Ziyuan Zhao, Theodoros Tsiligkaridis, Marinka ZitnikNeurIPS 2022 · 558 citations
- CoST: Contrastive Learning of Disentangled Seasonal-Trend Representations for Time Series ForecastingGerald Woo, Chenghao Liu, Doyen Sahoo, Akshat Kumar et al.ICLR 2022 · 468 citations
- TimesNet: Temporal 2D-Variation Modeling for General Time Series AnalysisHaixu Wu, Tengge Hu, Yong Liu, Hang Zhou et al.ICLR 2023 · 423 citations
- Self-Supervised Graph Neural Networks for Improved Electroencephalographic Seizure AnalysisSiyi Tang, Jared Dunnmon, Khaled Kamal Saab, Xuan Zhang et al.ICLR 2022 · 157 citations
- MBrain: A Multi-channel Self-Supervised Learning Framework for Brain SignalsDonghong Cai, Junru Chen, Yang Yang, Teng Liu et al.KDD 2023 · 16 citations
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