Searching for High-Value Molecules Using Reinforcement Learning and Transformers
Raj Ghugare, Santiago Miret, Adriana Hugessen, Mariano Phielipp, Glen Berseth
Abstract
Reinforcement learning (RL) over text representations can be effective for finding high-value policies that can search over graphs. However, RL requires careful structuring of the search space and algorithm design to be effective in this challenge. Through extensive experiments, we explore how different design choices for text grammar and algorithmic choices for training can affect an RL policy's ability to generate molecules with desired properties. We arrive at a new RL-based molecular design algorithm (ChemRLformer) and perform a thorough analysis using 25 molecule design tasks, including computationally complex protein docking simulations. From this analysis, we discover unique insights in this problem space and show that ChemRLformer achieves state-of-the-art performance while being more straightforward than prior work by demystifying which design choices are actually helpful for text-based molecule design.
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Cited by top-tier papers3
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- Regulatory DNA Sequence Design with Reinforcement LearningZhao Yang, Bing Su, Chuan Cao, Ji-Rong WenICLR 2025
Builds on12
- Language Models are Few-Shot LearnersTom B. Brown, Benjamin Mann, Nick Ryder, Melanie Subbiah et al.NeurIPS 2020 · 64,255 citations
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- Mastering Visual Continuous Control: Improved Data-Augmented Reinforcement LearningDenis Yarats, Rob Fergus, Alessandro Lazaric, Lerrel PintoICLR 2022 · 457 citations
- Multi-Objective Molecule Generation using Interpretable SubstructuresWengong Jin, Regina Barzilay, Tommi S. JaakkolaICML 2020 · 238 citations
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