Working With AI to Persuade: Examining a Large Language Model's Ability to Generate Pro-Vaccination Messages
Elise Karinshak, Sunny Xun Liu, Joon Sung Park, Jeffrey T. Hancock
Abstract
Artificial Intelligence (AI) is a transformative force in communication and messaging strategy, with potential to disrupt traditional approaches. Large language models (LLMs), a form of AI, are capable of generating high-quality, humanlike text. We investigate the persuasive quality of AI-generated messages to understand how AI could impact public health messaging. Specifically, through a series of studies designed to characterize and evaluate generative AI in developing public health messages, we analyze COVID-19 provaccination messages generated by GPT-3, a state-of-the-art instantiation of a large language model. Study 1 is a systematic evaluation of GPT-3's ability to generate pro-vaccination messages. Study 2 then observed peoples' perceptions of curated GPT-3-generated messages compared to human-authored messages released by the CDC (Centers for Disease Control and Prevention), finding that GPT-3 messages were perceived as more effective, stronger arguments, and evoked more positive attitudes than CDC messages. Finally, Study 3 assessed the role of source labels on perceived quality, finding that while participants preferred AI-generated messages, they expressed dispreference for messages that were labeled as AI-generated. The results suggest that, with human supervision, AI can be used to create effective public health messages, but that individuals prefer their public health messages to come from human institutions rather than AI sources. We propose best practices for assessing generative outputs of large language models in future social science research and ways health professionals can use AI systems to augment public health messaging.
CCS Concepts: • Human-centered computing → Empirical studies in HCI.
Ask about this paper
Your agent reads all of it.
Lune indexed this paper to the last equation, along with the top-tier papers that cite it. Ask a question and the answer quotes them.
Your agent calls
Luneget_paper_fulltext
Free to start. No credit card required.
Terminal
Install the CLIlune papers fulltext 7df4069a-9147-4976-a055-ee069b92a809Cited by top-tier papers22
- Debate Chatbots to Facilitate Critical Thinking on YouTube: Social Identity and Conversational Style Make A DifferenceThitaree Tanprasert, Sidney S. Fels, Luanne Sinnamon, Dongwook YoonCHI 2024 · 51 citations
- 'It was 80% me, 20% AI': Seeking Authenticity in Co-Writing with Large Language ModelsAngel Hsing-Chi Hwang, Q. Vera Liao, Su Lin Blodgett, Alexandra Olteanu et al.CSCW 2025 · 36 citations
- AI-Driven Mediation Strategies for Audience Depolarisation in Online DebatesJarod Govers, Eduardo Velloso, Vassilis Kostakos, Jorge GonçalvesCHI 2024 · 34 citations
- From Text to Trust: Empowering AI-assisted Decision Making with Adaptive LLM-powered AnalysisZhuoyan Li, Hangxiao Zhu, Zhuoran Lu, Ziang Xiao et al.CHI 2025 · 30 citations
- Perceptions of Sentient AI and Other Digital Minds: Evidence from the AI, Morality, and Sentience (AIMS) SurveyJacy Reese Anthis, Janet V. T. Pauketat, Ali Ladak, Aikaterina ManoliCHI 2025 · 24 citations
Builds on6
- Language Models are Few-Shot LearnersTom B. Brown, Benjamin Mann, Nick Ryder, Melanie Subbiah et al.NeurIPS 2020 · 64,255 citations
- Retrieval-Augmented Generation for Knowledge-Intensive NLP TasksPatrick Lewis, Ethan Perez, Aleksandra Piktus, Fabio Petroni et al.NeurIPS 2020 · 19,162 citations
- TruthfulQA: Measuring How Models Mimic Human FalsehoodsStephanie Lin, Jacob Hilton, Owain EvansACL 2022 · 3,228 citations
- Jury Learning: Integrating Dissenting Voices into Machine Learning ModelsMitchell L. Gordon, Michelle S. Lam, Joon Sung Park, Kayur Patel et al.CHI 2022 · 134 citations
- AI-Mediated Communication: Language Use and Interpersonal Effects in a Referential Communication TaskHannah Mieczkowski, Jeffrey T. Hancock, Mor Naaman, Malte F. Jung et al.CSCW 2021 · 83 citations
Related papers
- Towards AI-Driven Healthcare: Systematic Optimization, Linguistic Analysis, and Clinicians' Evaluation of Large Language Models for Smoking Cessation InterventionsPaul Calle, Ruosi Shao, Yunlong Liu, Emily T. Hébert et al.CHI 2024 · 20 citations
- Synthetic Lies: Understanding AI-Generated Misinformation and Evaluating Algorithmic and Human SolutionsJiawei Zhou, Yixuan Zhang, Qianni Luo, Andrea G. Parker et al.CHI 2023 · 283 citations
- "Can LLMs Persuade Humans with Deception?": From a Deceptive Strategy Taxonomy to a Large-Scale Empirical StudyHaein Yeo, Seungwan Jin, Taehyung Noh, Yejin Shin et al.CHI 2026 · 2 citations
- Presenting Large Language Models as Companions Affects What Mental Capacities People Attribute to ThemAllison Chen, Sunnie S. Y. Kim, Angel Nathaniel Franyutti-Cintron, Amaya Dharmasiri et al.CHI 2026 · 3 citations
- Personal Validation Effect in LLMs: Positive AI Responses Bias Perceptions of Validity, Reliability, Personalization, and Usefulness of Fictitious PredictionsPat Pataranutaporn, Eunhae Lee, Judith Amores, Pattie MaesCHI 2026 · 1 citation
