RecordTwin: Towards Creating Safe Synthetic Clinical Corpora

The scarcity of publicly available clinical corpora hinders developing and applying NLP tools in clinical research. While existing work tackles this issue by utilizing generative models to create high-quality synthetic corpora, their methods require learning from the original inhospital clinical documents, turning them unfeasible in practice. To address this problem, we introduce RECORDTWIN, a novel synthetic corpus creation method designed to generate synthetic documents from anonymized clinical entities. In this method, we first extract and anonymize entities from in-hospital documents to ensure the information contained in the synthetic corpus is restricted. Then, we use a large language model to fill the context between anonymized entities. To do so, we use a small, privacy-preserving subset of the original documents to mimic their formatting and writing style. This approach only requires anonymized entities and a small subset of original documents in the generation process, making it more feasible in practice. To evaluate the synthetic corpus created with our method, we conduct a proof-of-concept study using a publicly available clinical database. Our results demonstrate that the synthetic corpus has a utility comparable to the original data and a safety advantage over baselines, highlighting the potential of RECORDTWIN for privacy-preserving synthetic corpus creation 1 .